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KMID : 0377619710210030221
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Korean Jungang Medical Journal
1971 Volume.21 No. 3 p.221 ~ p.228
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The Effects of Splenectomy, Chlorphenesin, Chloramphenicol, and Cortisone on the Immune Response in Rabbits
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Abstract
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The present study was undertaken in order to investigate the effect of splenectomy, chlorphenesin, chloramphenicol and cortisone on the´ immune responses to goat red blood cells and Salmonella typhi H901 and 0901 (11901 and 0901) and the following results were obtained.
The agglutinating antibody titers to H901 and 0901, and the hemolysine titers to goat red blood cells were lower in splenectomized rabbits than in sham-opersted controls.
There was no significant difference in antibody titers to H901 and 0901 antigens in both control and splenectomized rabbits.
The hemolysin titer was some what higher in control and splenectomized rabbits when the antigens were given by intraperitoneal route than by intravenous and subcutaneous routes.
The hemolysin and agglutinating antibody to H901 and 0901 were characterized by peak in titer 14 or 21 days after the single injection of antigens, and thehemolysin titer slowly decline 28 days after the antigen injection.
The secondary immune response of splenectomized and control rabbits to goat= red blood cells and H901 antigens were observed when the second injection of the antigens was done 35 days after the first injection, suggesting the regenerated splenules in the splenectomized rabbits and nonsplenic antibody-forming organs may continue the synthesis of additional antibody by compensatory mechanism.
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